Clinical studies suggest that poor oral health can causes periodontal disease (PD) and chronic illness such as respiratory disease, cardiovascular disease, and diabetes and lead to poor quality of life, overall health, and nutrition. Although, the underlying mechanisms for this is still remain unclear; accumulating evidence suggest that impaired NO-dependent vasodilation may be one of the potential key factor(s) for observed vascular diseases in AA population. PD and Vascular Function. Endothelial dysfunction is the initial step in the development of ASVD. Reduced nitric oxide (NO) bioavailability as a result of endothelial nitric oxide synthase (eNOS) uncoupling and increased reactive oxygen species (ROS) has been known to play a detrimental role in cardiovascular pathologies. However the link between NO and PD with regards to systemic vascular function has not been yet demonstrated. PD and GI Motility Function: Understanding the role of the gut microbiome is among the most exciting areas of science today. To date, however, we know little about the oral microbiome and its association with gastrointestinal function, including motility. Here we sought to determine if induction of PD in mice by oral polymicrobial infection can alter BH4/nNOS/NRF2 pathways in vascular tissue, stomach and/or colon specimens..
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Last date updated on July, 2014