Cholera is a serve diarrheal disease that remains a major health risk in developing countries. As a causative agent of Cholera, the bacterium Vibrio cholerae remains responsible for significant morbidity and mortality worldwide. The emergence and spread of multi-drug resistance Vibrio cholerae strains during past two decades is now a major problem in the treatment of cholera and have created the urgent need for the development of novel therapeutic agents. Targeting transcriptional factor is now a novel approach to tackle the development of multi-drug resistance strain. Vs Bijendra Khadka , Computer based screening for novel inhibitors against V. cholerae using NCI diversity set-II and ZINC natural products database.
Last date updated on July, 2014