alexa Journals-on-structure-based-drug-discovery|OMICS International|Drug Designing: Open Access

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Journals On Structure Based Drug Discovery

The High-Throughput Screening (HTS) approach was regarded as the most powerful tool in processing the drug discovery. By identifying biologically active compounds against specific targets on an assay system with less complexity, the HTS approach offers pharmaceutical companies an in-house drug discovery strategy to select lead compound from a large scale of compound collections. Designed with the basis of “Key-Lock” principle, which was first described by Hermann Emil Fischer, the HTS approach could definitely develop a simple way to screen out leads against with a very high efficiency and productivity. Although the target-to-lead efforts in drug discovery, which involve the selection of targets, development of an assay, compound screening and validation of leads on a secondary assay, generally take 2 to 3 years in most of the pharmaceutical companies, the compound screening step using HTS approach typically takes from 1 week to 3 months. Vs Yibin Feng, The New Generation of Drug Discovery and its Analytical Technologies
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Last date updated on November, 2020