|Drug disposition is the knowledge about the fate of a drug such as its absorption, distribution, metabolism, and excretion, known by the acronym ADME and its pharmacokinetics. The pharmacokinetics describes the rates of these processes and of concentration-time relationships. In preclinical and early clinical drug development, information about the factors influencing drug disposition used to predict drug interaction potential, estimate and understand population pharmacokinetic variability, and select doses for clinical trials.
"Open access to the scientific literature means the removal of barriers (including price barriers) from accessing scholarly work. There are two parallel âroadsâ towards open access: Open Access articles and self-archiving. Open Access articles are immediately, freely available on their Web site, a model mostly funded by charges paid by the author (usually through a research grant). The alternative for a researcher is âself-archivingâ (i.e., to publish in a traditional journal, where only subscribers have immediate access, but to make the article available on their personal and/or institutional Web sites (including so-called repositories or archives)), which is a practice allowed by many scholarly journals.
Open Access raises practical and policy questions for scholars, publishers, funders, and policymakers alike, including what the return on investment is when paying an article processing fee to publish in an Open Access articles, or whether investments into institutional repositories should be made and whether self-archiving should be made mandatory, as contemplated by some funders."