alexa Drug Susceptibility|Journals Open Access|Drug Susceptibility

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Drug Susceptibility

"Based on the Stanford HIVdb algorithm, drug susceptibility was possibly significantly reduced in 36 patients (10.9%). Among the 15 cases (4.5%) with mutations conferring significant resistance to NRTIs, 10 (3.0%) had intermediate or high level resistance to AZT, D4T, only 3 (0.9%) and 4 (1.2%) patients were predicted to be obviously resistant to TDF and ABC. 5 patients (1.5%) were predicted to have high-level resistance to 3TC and FTC. When NNRTI mutations were present in 22 (6.7%) patients, almost all the patients were predicted to have intermediate to high-level resistance to EFV (n=21, 6.4%) and NVP (n=22, 6.7%), while quite a few patients were resistant to RPV and ETR (n=6, 1.8% and n=3, 0.9% respectively). Cases with PI resistance (n=9, 2.7%) tended to have intermediate or high-level resistance to NFV, seen in n=7, (2.1%) and SQV/r as seen in n=4 (1.2%) patients, who also remained susceptible or had only a potential low-level resistance to DRV/r. Only one (0.3%) patient from this cohort was predicted to have intermediate-level resistance to LPV/r and ATV/r, two patients (0.6%) were predicted to have intermediate-level resistance to FPV/r d TPV/r. OMICS Group International is one of the leading Open Access Publishers which is publishing 350 scholarly open access journals with the support of 30,000 well-versed scholars as editorial team and aimed to disseminate the scholarly knowledge to the scientific society. OMICS Group also organizing 100 international scientific conferences and events yearly all over the world with the support of 100+ scientific associations worldwide.
 
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