When treating pulmonary diseases such as asthma, COPD and CF, inhalation may be the best route of administration due to the rapid clinical response and the high doses of drug that can be administered to the disease site with limited off-target effects. However, a number of considerations need to be taken into account when designing new inhaled therapies. Direct drug delivery into the lung has proven to be advantageous for the treatment of chronic lung diseases due to the lower risk of side effects. However, such drugs must be poorly absorbed across the epithelia. More recently, groups are taking advantage of rapid pulmonary drug absorption and are investigating how to treat systemic diseases through pulmonary drug delivery since this allows for drug delivery that bypasses the stomach. (Jean Tyrrell and Robert Tarran, Gaining the Upper Hand on Pulmonary Drug Delivery)
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Last date updated on July, 2014