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Acute Cardiology

The role of mechanical forces in establishment and progression of the stenotic aortic valve pathology and the vein bypass graft failure has remained underestimated until few years ago. Today, the availability of engineering systems able to mimic the mechanical forces acting in these pathologies makes possible to perform ex vivo studies with human-derived cardiovascular tissues and stem cells isolated from the cardiovascular system. While this contributes to the comprehension of the molecular events underlying the pathology progression, it also significantly contributes to the devise of human tissue ‘conditioning protocols’ and of advanced tissue engineering strategies able to impact on the outcome of these outstanding pathologies. Our group has a R&D program in cardiovascular tissue engineering exploiting the latest advancements in the design of bioreactors and lab-on-chip devices, with the aim at investigating the mechanical causes of human aortic valve stenosis and the venous bypass failure. During the course of the presentation, original/unpublished results will be presented and discussed in the context of the latest advancements in molecular progression of these pathologies. Maurizio Pesce, Modified mechano-perception and altered mechanical stress: Novel insights in stenotic valve and bypass pathology
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Last date updated on June, 2014

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