OMICS Group International is a scientific organization that promotes open access for relevant scientific information and research findings. About 700+ peer-reviewed journals are handled by more than 25000 editorial board members who belong to both academic and industrial circles in all aspects of Science, Engineering, Management and Technology journals. A collaboration set up recently with 100 international societies would provide a window to wider knowledge-base of worldwide open access health-related information. As part of its drive to boost knowledge-sharing through real-time interaction, this open access group has been organizing over 100 world-class scientific conferences at global venues through the calendar year. Abstracts presented at the meets are invited from scholars with a track record of effective research papers that are also published as special journal issue for each of the conference. Apart from India and the US as established locations, the events would soon expand to several continents to add the regional touch through collaboration with scientific and healthcare bodies in respective geographies like Europe, Australia and the Middle East. Most of the international conferences comprise of day-long programs in the form of symposiums or workshops, which serve as a specialized program within the main event. Realizing the potential of open access in terms of greater visibility within and beyond the scientific community, in recent years, there has been a tremendous breakthrough to open access movement through various open access publishers. OMICS is one such publishing group that believes in this movement and is most ardently working towards the welfare and progress of scientific community.
Enzyme inhibitors are molecules that bind to enzymes and lower their activity. Many drugs are enzyme inhibitors due to the correction of metabolic imbalance may occur, as a result of blocking an enzyme activity. Therefore, the discovery of enzyme inhibitors is an active area of research in biochemistry and pharmacology. Not all molecules that bind to enzymes are inhibitors; enzyme activators bind to enzymes and elevate their enzymatic activity. Inhibitor binding is either reversible or irreversible. Usually, irreversible inhibitors react with the enzyme and change it chemically. Reversible inhibitors bind non-covalently to produce different types of inhibition, depending on whether these inhibitors bind the enzyme, the enzyme- substrate complex, or both. There are different types of reversible inhibition that may be competitive, non-competitive types and uncompetitive, although a mixed type sometimes arises. Non-competitive inhibition is a form of inhibition where the binding of the inhibitor to the enzyme reduces its activity, but does not affect the binding of substrate. However, an allosteric effect occurs where the inhibitor binds to a different site on an enzyme. The value of the inhibition constant (Ki) is used as an indication for the degree of enzyme inhibition. (Mahmoud Balbaa and El Sayed H. El Ashry, Enzyme Inhibitors as Therapeutic Tools)
Last date updated on July, 2014