Esophago-Gastric Junction; SCJ: Squamo-Columnar Junction; PLEV: Palisading Longitudinal Esophagus Vessel; H. pylori:
Helicobacter pylori; BE: Barrettâs Esophagus; SSBE: Short Segment Barrettâs Esophagus; GERD: Gastro-Esophageal Reflux Disease
The incidence rate of gastric cancer in Japan is one of the highest in developed countries. Infection by Helicobacter pylori (H. pylori)
and gastric atrophy have also been associated with the development of gastric cancer. On the other hand, association of H. pylori
infection with the risk of stomach cancer is restricted to the noncardia region, while the cardia region shares the same risk factors as the
distal part of esophagus, for which an inverse association of H. pylori infection with esophageal adenocarcinoma has been reported. An increase in the incidence of esophageal adenocarcinoma and
gastric cardia cancer has been reported in Western countries. On the other hand, in Japan, where both Barrettâs esophagus (BE)
and esophageal adenocarcinoma are far more uncommon than in Western countries, the increase seems to be slight as is that of BE.
However, the lack of universally accepted criteria for the esophagogastric junction (EGJ) continues to result clinically in confusion in
diagnosis of Barrettâs esophagus, not only in Japan but also in Western countries. Therefore, it is difficult to know true incidences of gastric
cardia cancer, esophageal adenocarcinoma and BE, particularly short segment Barrettâs esophagus (SSBE).
Last date updated on July, 2014