"Hypoglycaemia is a significant risk with insulin and some sulphonylureas, especially long acting preparations. Older people with both T1DM and T2DM are particularly vulnerable to hypoglycaemia: it is the most frequent metabolic complication in older people and may account for one in five hospital admissions in older people with diabetes aged 80 years and older. The GLM prescribed, often the long acting sulphonylurea glibenclamide, may have been inappropriate in a large number of people who had dementia and/or renal failure in Greco et alâs study. Hypoglycaemia is associated with longer hospital stay and increased costs in T2DM. It is often difficult to detect in older people because neuroglycopaenic symptoms predominate and can be misinterpreted for confusion and not treated. Significantly, hypoglycaemia is associated with short term changes in delayed and working memory and dementia in the longer term and can precipitate myocardial infarction.
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Last date updated on March, 2021