This describes us about the growth pattern of a microbe in a fermenter. This factor has its own significance in determining the best batch timing for product recovery. A typical microbial growth curve is explained on the basis of a typical batch type fermentation which includes Lag phase, Logarithmic/Exponential phase, Static/Stationary phase and Death/Decline phase. Lag Phase is where we find no growth or very minimal growth in the fermenter. Reasons behind are inoculum inoculated into medium need to be adapted to the new environment. In Logarithmic/Exponential phase inoculum got adapted to the environment, here we observe fast growth in population due to rapid division of adapted inoculum and with this phase we find the highest cellular growth rate and rapid utilisation or uptake of nutrients or substrate. As the time passes, the logarithmic increase of microbial population will get constant due to substrate limitation. Static/Stationary Phase is the phase where the growth in microbial population ceases and an equilibrium state exists among the number of cells dividing and number of cells dying. Reasons for growth cease are depletion of essential growth nutrients, accumulation of toxic by-products. Here we observe the formation of non-growth associated products. Death/Decline phase is the final stage of the microbe in its growth cycle. Here, the number of cells dying will be more than that of the number of cells dividing.
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Last date updated on April, 2021