Aspirin (acetylsalicylic acid), is therapeutically used as an analgesic with fewer adverse reactions than salicylic acid. Through acetylation it was first generated as an antipyretic analgesic from of salicylic acid in the late 19th century. Worldwide aspirin has long been used as an ingredient in anti-inflammatory agents. It has much therapeutic action which includes antiinflammatory, antipyretic and analgesic effects, as well as antiplatelet and antirheumatic effects. Aspirin has been used as a prescription drug and nonprescription (over-the-counter) drug, and demand for the drug has steadily increased. Yet times over dosage of aspirin leads to poisonous cases. Toxicological analysis showed high concentrations of the active metabolite of aspirin, salicylic acid, in the blood and brain. Metabolic acidosis that is characteristic of salicylism increases the distribution of salicylic acid into the brain. Scholarly peer review is the process of subjecting an author's scholarly work, research, or ideas to the scrutiny of others who are experts in the same field, before a paper describing this work is published in a journal. The work may be accepted, considered acceptable with revisions, or rejected. Peer review requires a community of experts in a given (narrowly defined) field, who are qualified and able to perform reasonably impartial review.
Last date updated on July, 2014