STR Markers Articles

Three sets of commonly used autosomal short tandem repeat (STR) markers and 14 databases from populations were used to investigate how the selection of the population database and the number of considered markers would influence the statistical evidence that is usually produced to favour paternity. In recent years a growing number of disputed paternities have involved parents from different ethnic backgrounds. We examined how sensitive the Paternity Index (PI) , the Probability of Paternity (W) and the Probability of Exclusion (PE) [are to the selection of the population STR database and to the number of considered STR markers. To evaluate this we performed paternity tests on 100 Finnish trios and duos with three sets of commonly used STR markers and 14 population databases, representing different marker allele frequencies. Such frequencies are estimated for each specific population and will generally vary between populations. As a consequence, calculating probabilities using different population data means differences in the probabilities' values. Concerning the 'Database Effect' we carried out a comparative statistical analysis of PI and W which were at first calculated considering the allele frequencies of the putative father's own population (Finnish), and then using some other reference population databases. Forensic paternity testing is conducted using DNA profiles which consist of genotyping of several highly polymorphic short tandem repeat (STR) markers, chosen on different chromosome in order to ensure an independent segregation. Mutation can sometimes cause an apparent discrepancy with the rules of inheritance between parent and child, but the incompatibility in at least three independent DNA markers is widely seen as sufficient evidence to exclude paternity. A journal is a periodical publication intended to further progress of science, usually by reporting new research. Most journals are highly specialized, although some of the oldest journals publish articles, reviews, editorials, short communications, letters, and scientific papers across a wide range of scientific fields. Journals contain articles that peer reviewed, in an attempt to ensure that articles meet the journal's standards of quality, and scientific validity. Each such journal article becomes part of the permanent scientific record.

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Last date updated on April, 2024