|Aspirin (acetylsalicylic acid), is therapeutically used as an analgesic with fewer adverse reactions than salicylic acid. Through acetylation it was first generated as an antipyretic analgesic from of salicylic acid in the late 19th century. Worldwide aspirin has long been used as an ingredient in anti-inflammatory agents. It has much therapeutic action which includes antiinflammatory, antipyretic and analgesic effects, as well as antiplatelet and antirheumatic effects. Aspirin has been used as a prescription drug and nonprescription (over-the-counter) drug, and demand for the drug has steadily increased. Yet times over dosage of aspirin leads to poisonous cases. Toxicological analysis showed high concentrations of the active metabolite of aspirin, salicylic acid, in the blood and brain. Metabolic acidosis that is characteristic of salicylism increases the distribution of salicylic acid into the brain. The top open access journals are freely available on the public internet domain, allowing any end users to read, download, copy, distribute, prink, search or link to the full texts of the articles. These provide high quality, meticulously reviewed and rapid publication, to cater the insistent need of scientific community. These journals are indexed with all their citations noted. The top open access journals are indexed in MEDLINE, PUBMED, SCOPUS, COPERNICUS, CAS, EBSCO and ISI.