Gabapentin is an anticonvulant which have been widely used for pain control in different medical situations. These aminobutyric acid analogues have shown analgesic anti -nociceptive effects in different pain situations. Gabapentin is a GABA analogue and its possible mechanism of actions are binding to the alpha-2 delta subunit of the presynaptic voltage gated-calcium channels and inhibiting calcium release. It also has interaction with NMDA receptor and causes reduction in substance P and glutamate which could show preventive effects on central nervous system excitability by this mechanism of action. Its positive effects on neuropathic and postoperative pain control have been evaluated in different studies. Gabapentin is the precursor of pre-gabalin the other discussed drug.
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Last date updated on January, 2021