Gabapentin is an anticonvulant which have been widely used for pain control in different medical situations. These aminobutyric acid analogues have shown analgesic anti -nociceptive effects in different pain situations. Gabapentin is a GABA analogue and its possible mechanism of actions are binding to the alpha-2 delta subunit of the presynaptic voltage gated-calcium channels and inhibiting calcium release. It also has interaction with NMDA receptor and causes reduction in substance P and glutamate which could show preventive effects on central nervous system excitability by this mechanism of action. Its positive effects on neuropathic and postoperative pain control have been evaluated in different studies. Gabapentin is the precursor of pre-gabalin the other discussed drug.
The top open access journals are peer reviewed scholarly journals of Journal of Pain & Relief. The top open access journals are freely available on the public internet domain, allowing any end users to read, download, copy, distribute, prink, search or link to the full texts of the articles. These provide high quality, meticulously reviewed and rapid publication, to cater the insistent need of scientific community. These journals are indexed with all their citations noted. The top open access journals are indexed in MEDLINE, PUBMED, SCOPUS, COPERNICUS, CAS, EBSCO and ISI.
Last date updated on September, 2014