RNA has recently emerged as an important nanotechnology platform due to its extraordinary diversity in structure and function. Small interfering RNA (siRNA), showed significant potential in new molecular approaches to down-regulate specific gene expression in mammalian cells. In fact, targeted gene suppression by antisense DNA and siRNA has shown promising preclinical results, and/or is currently in clinical trials for a variety of diseases, including many forms of cancer (e.g., melanoma, neuroblastoma, and pancreatic adenocarcinoma), genetic disorders, and macular generation . Despite the high therapeutic potential of siRNA, its application for clinical medicine is still limited mainly due to the lack of appropriate delivery systems. In such a situation, the development of clinically suitable, safe, and effective drug-delivery biomaterials are required for the widespread use of siRNA therapeutics for disease treatment. Gene Silencing by siRNA Nanoparticles Synthesized via Sonochemical Method: Shimanovich U, Munder A, Loureiro A, Azoia NG, Gomes A, Cavaco-Paulo A, Gedanken A and Gruzman A. Scholarly journals provide a greater visibility in the growing scientific field. For presenting the on-going research and exciting discoveries within the realms of many Scholarly journals that have been started, which are playing a major role in enhancing the dissemination of natural and scientific knowledge. Scholarly Journals are journals which are respected for the research and information they provide about the topic they cover. Scholarly journals publish good quality articles by subjecting them to a thorough and careful peer review process. Articles are often anonymously reviewed by several other subject experts; this process is called "peer review process" and such a periodical is considered a "refereed journal. A scholarly journal presents rigorously peer-reviewed scientific articles in the following categories: original Research Articles, Communications, Reviews and Mini-Reviews, Commentaries and Letters to the Editor. OMICS Group International is one of the leading Open Access Publishers which is publishing 700+ peer-reviewed journals with the dramatic effort of editorial board members. Molecular Biology publishes original research articles, novel, and scientifically sound findings dealing with genes related living organism.
Last date updated on July, 2014