"Genetic studies often require the recruitment of large numbers of subjects with certain physical or physiological characteristics and ascertainment of DNA samples. In the past, most blood samples were obtained by venipuncture requiring trained staff. In our experience and in the experience of others, participation rates can be low when phlebotomy is involved since some study subjects may be reluctant to have their blood drawn. Reasons for non-participation if blood drawing is involved include fear of needle stick in healthy individuals, reluctance of going through yet another procedure in subjects with health problems, veins that are difficult to access or hesitation of recruiters and caretakers to draw blood from elderly and feeble ndividuals or from young children. When there is a choice, most requested participants prefer saliva samples, buccal cell samples via mouth swabs or buccal cell samples on FTA cards. Until recently, blood or tissues were the main sources for isolating sufficient amounts of genomic DNA for genetic studies.
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Last date updated on December, 2020