Hereditary nonpolyposis colorectal cancer (HNPCC) is the most common form of hereditary colorectal cancer. It is inherited as an autosomal dominant syndrome, as a result of defective mismatch repair (MMR) proteins. HNPCC accounts for 2-5% of all colorectal carcinomas.There are a number of different inherited conditions that have a significant risk of colon cancer.It is estimated that 1550% of colorectal cancers are familial. A single gene, a combination of genes, or a combination of genetic and environmental factors can cause familial colorectal cancer. Typically these families have one or two members with a history of colorectal cancer or precancerous polyps.Inherited colorectal cancers are associated with a genetic mutation in a cancer susceptibility gene. Everyone inherits one susceptibility gene from each of their parents, making a total of two working copies of each gene. If a mutation in one copy of a cancer susceptibility gene is passed from the parent to their child, the child is predisposed (or has the potential) to develop cancer.
The open access journals are peer reviewed scholarly journals of Hereditary Genetics Current Reserach. The top open access journals are freely available on the public internet domain, allowing any end users to read, download, copy, distribute, prink, search or link to the full texts of the articles. These provide high quality, meticulously reviewed and rapid publication, to cater the insistent need of scientific community. These journals are indexed with all their citations noted. The top open access journals are indexed in SCOPUS, COPERNICUS, CAS, EBSCO and ISI.
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Last date updated on July, 2014