Genome annotation is a process that includes prediction of protein-coding genes which includes Structuralâ genome annotation in which genes are identified along with intron and exon structures and the functional aspect of genome units such as pseudogenes, tRNAs, control regions, structural RNAs, small RNAs, direct and inverted repeats, insertion sequences including transposons. Genome analysis can be done by computational means which are later deposited in GenBank after approval. Ever since the discovery of sequencing techniques began, scientific field has been inundated with much information about genes and their transcripted and translated products. But the advent of Next-Sequencing technologies have not only improved our understanding of molecular biology of life, but also created a huge problem of repeated data during sequencing. Annotation of this genetic information has become a herculean task for computational biologists and bioinformaticians to annotate them. Many algorithms and approaches have been designed to annotate the sequenced data and it is still an ongoing process.
Last date updated on May, 2014