Proteoglycans are proteins that are heavily glycosylated it's a organic compound composed of a saccharide joined to a peptide and forming the bottom substance of animal tissue (or) any of a category of glycoproteins of high relative molecular mass that are found particularly within the extracellular matrix of animal tissue and even have lubricator and support functions. The fundamental proteoglycan unit consists of a "core protein" with one or a lot of covalently connected glycosaminoglycan (GAG) chain(s). The purpose of attachment may be a Ser residue to that the glycosaminoglycan is joined through an oligosaccharide bridge (e.g. chondroitin sulfate-GlcA-Gal-Gal-Xyl-PROTEIN). The Ser residue is usually within the sequence -Ser-Gly-X-Gly- (where X is any organic compound residue, however Proline), though not each supermolecule with this sequence has associate connected glycosaminoglycan. The chains are long, linear macromolecule polymers that are charged underneath physiological conditions, because of the incidence of sulphate and uronic acid teams. Proteoglycans occur within the animal tissue. A high relative molecular mass advanced of supermolecule and saccharide, characteristic of structural tissues of vertebrates, like bone and animal tissue, however conjointly gift on cell surfaces. vital in crucial elastic properties of joints and different structures subject to mechanical deformation. Glycosaminoglycans (gAGs), the saccharide units in proteoglycans, are polymers of acidic disaccharides containing derivatives of the amino sugars glucosamine or galactosamine.
Last date updated on August, 2014