|Vitiligo is a disease that causes the loss of skin color in blotches. The extent and rate of color loss from vitiligo is unpredictable. It affect the skin on any part of your body, hair, inside of the mouth and even the eyes.Vitiligo occurs when the cells that produce melanin die or stop functioning. Vitiligo affects people of all skin types. The main sign of vitiligo is color (pigment) loss that produces light or white patches on your skin. Usually, the discoloration first shows on sun-exposed areas, such as the hands, feet, arms, face and lips. Vitiligo signs include skin discoloration, premature whitening or graying of the hair on your scalp, eyelashes, eyebrows or beard, loss of color in the tissues that line the inside of your mouth and nose, loss of or change in color of the inner layer of the retina, discolored patches around the armpits, navel, genitals and rectum. Depending on the type of vitiligo, the discolored patches may cover in many parts of your body, only one side or part of your body and one or only a few areas of your body. Vitiligo may be caused due to Family history, disorder in which your immune system attacks and destroys the melanocytes in the skin or a trigger event, such as sunburn, stress or exposure to industrial chemicals
Review articles are the summary of current state of understanding on a particular research topic. They analyze or discuss research previously published by scientist and academicians rather than reporting novel research results. Review article comes in the form of systematic reviews and literature reviews and are a form of secondary literature. Systematic reviews determine an objective list of criteria, and find all previously published original research papers that meet the criteria. They then compare the results presented in these papers. Literature reviews, by contrast, provide a summary of what the authors believe are the best and most relevant prior publications. The concept of "review article" is separate from the concept of peer-reviewed literature. It is possible for a review to be peer-reviewed, and it is possible for a review to be non-peer-reviewed.