Leiomyomas, benign neoplasms of mesenchymal origin, are quite common in places such as the gastrointestinal and genitourinary tracts. They are comprised of well-differentiated smooth muscle cells with few mitotic figures . By convention, leiomyomas should not exhibit metastatic potential, though there have been several reported cases of metastatic leiomyomas to the lungs, heart, lymph nodes, intraperitoneal cavity, soft tissue and muscle, breast, peripheral nerves, spinal cord and skull base . Primary intracranial lesions remain rare. Only 17 such cases have been reported and of those, only 3 are in confirmed immunocompetent patients. Primary intracranial leiomyomas are a rare entity and even rarerin an immunocompetent patient. The majority of intracranial leiomyomas are discovered in immunocompromised patients Their immunosuppression stems from HIV infection, pharmacologic suppression after organ transplantation, or genetic disorders such as
common variable immunodeficiency syndrome. Many of the lesions in this patient population are positive for EBV .In our patient, however, the immune system was intact and the lesion was negative for EBV, making a total of 4 cases in the immunocompetent patient reported in the literature.
Michele R Aizenberg, Primary Intracranial Leiomyoma in Immunocompetent Patients: Case
Report, Review of Literature and Treatment Recommendations
Last date updated on May, 2021