"Many proteins involved in hemostasis and blood coagulation pathways were observed as consistently upregulated through different studies. Proteins were also enriched in pathways for the clotting cascade and O and CO2 exchange in erythrocytes. These proteins are cross annotated to GO terms for blood coagulation, platelet activation, platelet degranulation, and wound healing. There is a delicate balance between opposing coagulation factors and we see a greater upregulation of pro-coagulation factors promoting a hyper-coagulative state. Pregnancy is normally associated with a hypercoagulative state induced by increased pro-coagulation factors as well as reduced anti-coagulation factors.
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Citation: Wong F, Cox B (2014) Proteomics Analysis of Preeclampsia, a systematic Review of Maternal and Fetal Compartments. J Proteomics BioinformS10: 001."
Last date updated on May, 2021