Hepatitis C virus (HCV) has been implicated in many systemic diseases other than liver disease. At least 36 extra-hepatic disease manifestations, mainly autoimmune disorders, have been reported to be associated with HCV infection. The list of extra-hepatic manifestations is expanding. The extra-hepatic disease manifestations have been taken as evidence that HCV has tropism for cells other than hepatocytes, particularly lymphocytes. It has been postulated that HCV infection of lymphocytes is the cause of a many of autoimmune phenomena reported to be associated with HCV infection.
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Last date updated on December, 2020