"HIV genotype testing was performed by commercial laboratories test kit, GenoSureTM, and results were reported to the state or local health department. Only protease and reverse transcriptase sequences of the pol gene were reported. TDR was de?ned as the detection of 1 or more mutations in the surveillance drug resistance mutations (SDRMs) listed by the World Health Organization. This guideline optimizes the specificity of TDR classification for epidemiologic studies by including only mutations that are rarely selected for without drug pressure, and by excluding common polymorphic mutations (includes mutations that have a prevalence of at least 1% in treated persons and omits those mutations that are = 0.5% in treatment-naive persons in any subtype. ARV specific predicted resistance was calculated using code developed by Frontier Science and scores from the Stanford HIVDB algorithm, version 6.2.0. ARVs were categorized by class. Predicted resistance to specific antiretroviral drugs was defined as sequences with intermediate or high level resistance according to the Stanford HIVDB 5-point resistance scale.
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Last date updated on July, 2014