"Nowadays, RNA-based research is emerging as a crossing point among the natural and engineering sciences. It is an area of exciting discoveries that includes many different scientific and technological fields. In fact, many naturalsciences, includingchemistry and biology along with many types of chemical and biological engineering at a molecular and sub-molecular level are involved in modern medicine. The progress achieved by the next generation sequencing (NGS) technologies in recent years led to the discovery of novel targets for drug development and diagnostics. The interplay among RNA engineering, RNA biology, NGS technologies, and medical genomics creates new possibilities for drug development and molecular diagnostics. In this review, I presentcurrent and future RNA-based approaches to medical genomics as the focus set on drug development, molecular diagnostics and forthcoming RNA-based therapeutic strategies.
Genome-wide searches revealed that riboswitches are present mainly in bacteria. In addition, a few riboswitch classes are also found to control gene expression in some eukaryote species by alternative splicing. The genome-wide search of bacterial riboswitches has important applications to medical genomics. Robert Penchovsky, Present and Future RNA-based Approaches to Medical Genomics
Last date updated on June, 2014