The HIV-1 epidemic in African countries is mainly due to HIV-1 Subtype C compared to USA and Europe where is mainly subtype B. Patterns and frequency of antiretroviral drug resistance mutations observed in developing world may differ from HIV-1 subtype B predominates prevalent in developed world. The development of drug resistance among patients on antiretroviral therapy (ART) remains an important challenge in the management of HIV disease.
Patterns of drug resistance mutations in response to antiretroviral drugs and their impact on ART management have been extensively studied in patients with HIV-1 subtype B in the developed world, but limited information is available in patients from resource-limited settings who bear a disproportionate burden of the AIDS epidemic with diverse pool of non-B HIV-1 subtype.
The information obtained from this study will provide us with knowledge on the patterns and frequency of mutations associated with antiretroviral drug resistance among individual infected by different HIV-1 subtypes in Northern Tanzania. Furthermore, the study will show us on how different HIV-1 subtypes exposed to different antiretroviral regimes respond and enable us make good choice of antiretroviral regimens. Elichilia Robert Shao, Prevalence of HIV-1 subtypes and mutations with known association to antiretroviral therapy resistance among individuals aged 14 years and above in Northern Tanzania
Last date updated on June, 2014