|"The hydroxylation pattern of the ring structure, and the substitution of the 3-position: flavonols, flavones, flavones, flavanones, flavanols, anthocyanidins. In vitro and in situ blood brain barrier (BBB) studies have been reported that flavonoides can cross the BBB with considerable variation in permeability for different flavonoides depending on its structure. However the sensitive of cerebral tissue tonaturally occurring flavonoides and synthetic derivatives have been poorly considered and little is known about their pharmacological potential for therapy of malignant gliomas.
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Citation: Costa SL (2014) Antiglioma Potential of Flavonoides. J Bioanal Biomed 6: e124."