Cardiotonic steroids play a key role in sodium excretion in response to volume expansion. Their effect is mediated through their binding to the Na/K-ATPase, a membrane ion transporter which has recently been found to serve as scaffolding and signaling protein.Review articles are the summary of current state of understanding on a particular research topic. They analyze or discuss research previously published by scientist and academicians rather than reporting novel research results.
Review article comes in the form of systematic reviews and literature reviews and are a form of secondary literature. Systematic reviews determine an objective list of criteria, and find all previously published original research papers that meet the criteria. They then compare the results presented in these papers. Literature reviews, by contrast, provide a summary of what the authors believe are the best and most relevant prior publications.
The concept of "review article" is separate from the concept of peer-reviewed literature. It is possible for a review to be peer-reviewed, and it is possible for a review to be non-peer-reviewed.
The focus of this editorial is to the tradeoff this creates between natriuresis in the short term and progression of cardiac and renal fibrosis in the long term.
Last date updated on September, 2014