|"Photodynamic therapy (PDT) and holds substantial promise in improving outcomes of patients with a form of cutaneous conditions and dermatological conditions such as keratosis and basal cell carcinoma, etc. Use of 5-aminolevulinic acid (ALA) was sanctioned as secure and effective for use as a treatment. The combination of nanoformulation and Photodynamic therapy (PDT) has become one of the leading research topics. Phototherapy is a promising strategy used in the treatment with activation of photosensitizing drugs of particular wavelengths of lights which produces energy transforming into cytotoxic reactive oxygen which render apoptotic and necrotic cell death.
ALA with PDT are used for various treatments of skin across the world. Application of ALA with Photodynamic therapy is modality used on several skin cancerization treatments. However, because of the non- bioavailability locally, instable, less penetrating capacity into the cell membranes leads to limited activity of ALA with PDT. This limitation has to be overcome to enhance the efficacy of ALA with PDT. There are various modes of delivering ALA such as by patch method, applying laser, microneedles, microemulsion. A lot of research studies have been carried out to know the drug delivering systems for ALA.
Use of ALA with Photodynamic therapy against different skin cancerization has significant effects. However, the effect of efficacy varied according to the type of carcinoma. The study also highlights the efficacy of ALA with PDT among male and females with respect to age, which is one of the few studies, which had reported efficacy of ALA with Photodynamic therapy based on age and sex of the patients. In addition, our study suggests use of ALA-PDT as a simple, cost effective, and novel method that can be used for various skin cancerization treatments.