Oral squamous cell carcinoma (OSCC) is the most frequent type of head and neck cancer. Aim of the present study was to evaluate the expression and distribution of Substance P (SP) in different grades of OSCC and the potential of SP as a diagnostic marker. 40 OSCC biopsies (29 males and 11 females) were immunohistochemiscally analyzed by using SP antibody. 14 cases were well differentiated, 14 were moderately differentiated and 12 were poorly differentiated. Maximum cases fall in the age range of 41-60years and 16 in 61-80 years. Mean age of females was 53.54 years while males were 51.24 years. 62% of cases were SP positive. Most of the positive cases were from floor of the mouth and belonged to the age group 41-60 years. 93% of moderately differentiated, 92% of poorly differentiated and 8% of well differentiated carcinoma cases were positive for SP. SP expression intensity was maximum in poorly differentiated cases having +3 intensity. More patients were males and having grade moderately and poorly differentiated while more females belonged to well differentiated group. 68.96% of males were positive while only 45.45% of females were positive. Among all OSCC positive cases, 48% belonged to poorly differentiated, 48% to moderately differentiate and 4% to well differentiate. Strong expression of SP in poorly and moderately differentiated OSCC suggests a role of SP in progression and development of tumor. SP antagonists can help in reduction and inhibition of oral cancer.
Last date updated on July, 2014