Haematopoietic stem cell transplantation (AHSCT) is becoming a preferred treatment of unfavourable high-risk solid tumours in children. Malignant tumours that require AHSCT treatment are considered rare. These can be lymphomas or solid tumours such as neuroblastomas, Ewingas sarcomas/primitive neuroectodermal tumours (PNET), rhabdomyosarcomas, nephroblastomas, brain tumours and germ-cell tumours.
Indications for stem cell transplantation include disseminated high-risk tumours or tumours with an expected short survival using conventional treatment (expected long-term survival < 30%). AHSCT is also indicated in cases of partial response to induction therapy and disease relapse.
Here we present the results of patients who were treated for solid malignant tumours and lymphomas with high-dose chemotherapy and autologous haematopoietic stem cell transplantation as well as specific issues and solutions encountered in every-day practice in AHSCT.
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Last date updated on July, 2014