One area of research that is most promising and currently least developed is in silico design of biomaterials as well as scaffold design. Although much work has been done on use of finite element and other continuum based approaches to model scaffold characteristics, degradation of the scaffold-cell constructs over time is not well understood and investigated. Scaffold degradation behavior is primarily modeled through existing degradation models of polymers, while the nanocomposite scaffold materials exhibit degradation mechanisms, fairly different from those of pristine polymers. Further, extensive molecular models of materials of scaffolds present a significant design parameter that would require extensive studies in multiscale modeling to develop robust predictive capabilities of scaffolds over the time scale of degradation and cellular attachment, migration, proliferation and differentiation.
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Last date updated on September, 2020