The innate immune response to an infection is a first line rapid reaction consisting of two elements: recognition of invading microorganisms and complex biochemical and cellular consequences of this fact. The innate immune response has been regarded as relatively non-specific but sensitive. The cellular elements of innate immunity are represented by phagocytic cells and antigen-presenting cells-granulocytes, macrophages and dendritic cells (DCs) respectively, cytotoxic NK cells, Î³Î´ T lymphocytes. The innate immune system recognizes conserved microbial structures called pathogen-associated molecular patterns that have been implicated in activating the host innate response. These structures are sensed by germ lineencoded pattern recognition receptors (PRRs) represented by Toll-like receptors (TLRs) expressed at the cell surface or intracellularly and Nod-like receptors. The early immune reaction includes complement activation, phagocytosis and immune activation by different families of PRRs.
Innate Response to Infection-Malgorzata Lipinska-Gediga
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Last date updated on June, 2014