Dementia, encompassing deficits in several cognitive domains that are severe enough to interfere with daily functioning, in the new DSM V classification is classified within the broad category of major neurocognitive disorders, proposing specific criteria for the various etiologies. Previously defined as the manifestation of deteriorating brain functions over time due to cell deaths in the brain caused by neurodegeneration or any other disease, according to recent research dementia is not primarily caused by neuronal cell death/loss, but by dysfunction and loss of synapses in AD and in synucleinopathies. Other causes include cholinergic neuronal and axonal abnormalities, as well as pre- and postsynaptic cortical cholinergic deficits also occurring in early AD.
Internal Medicine Open Access, an official journal of OMICS International publishes all the articles related to dementia. The journal is subjecting all the received manuscripts to a strict peer review process. The articles published in the journal are Open Access i.e, freely accessible to readers all around the world. Internal Medicine Open Access is maintaining the quality of articles through its strict peer review process.
Last date updated on July, 2014