|Sickle cell anemia (SS) is an inherited chronic inflammatory and degenerative disease in which hemoglobin S (Hb S) is produced. Deoxy Hb S polymerizes and initiates a series of pathophysiologic events including decreased deformability of RBC, vaso-occlusion and tissue damage due to ischemia. The phenotypic expression of the disease varies from mild to severe depending on the specific genotype, gene modifiers, epigenetic and psychosocial factors. In its severe form, the disease is characterized by recurrent acute painful crises, severe anemia and organ damage.
Internal Medicine Open Access, an official journal of OMICS International publishes all the articles related to sickle cell anemia. The journal is subjecting all the received manuscripts to a strict peer review process. The articles published in the journal are Open Access i.e, freely accessible to readers all around the world. Internal Medicine Open Access is maintaining the quality of articles through its strict peer review process.