Systemic lupus erythematosus (SLE) is a multi- systemic auto immune connective tissue disease. Its aetiology is still poorly understood, though factors such as genetic, environmental, hormonal and immunologic have been implicated in its aetiopathogenesis. The major factor is genetic. B cells produce autoantibodies that mediate tissue injuries by many mechanisms. Also abnormal T cell signaling and gene expression lower T cell activation threshold and facilitate production of pro-inflammatory cytokines. Environmental factors such as UV light, ionising radiation, exposure to heavy metals, drugs and viruses have also been implicated. Apoptotic debris also plays a role by being source of auto antigens.
Internal Medicine Open Access Journal publishes almost all the papers related to Disorders. The journal has a highly qualified professors and associate professors as its editorial board members. These experts after thorough peer review process will make a decision whether a manuscript can be accepted for publication or not.
Last date updated on June, 2014