|Neuropathic pain has recently been redefined by the Neuropathic Pain Special Interest Group (NeuPSIG) to correspond to âpain initiated or caused by a primary lesion or dysfunction in the nervous systemâ . The need for modeling diabetic neuropathic pain comes from a clinical reality: diabetes is one of the largest providers of neuropathy in the world. Neuropathy occurs for both type 1 diabetes mellitus (T1DM) and type 2 diabetes mellitus (T2DM), suggesting that hyperglycemia is the primary etiologic factor. The most frequent clinical form is by far the diabetic distal sensory or sensorimotor polyneuropathy, affecting 30% of community-based people with diabetes. Sensory polyneuropathy presents a typical distribution âin stocking and gloveâ, and can sometimes be asymptomatic but usually causes abnormal sensations (paresthesia and dysesthesia) and/or pain. Here, the longest fibers are first affected, which explains the distal distribution.
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