Neuropathy is the most common complication of diabetes, occurring in 60% of diabetic patients, and it causes significant morbidity and mortality. Over the past 30 years, diabetic neuropathy has been shown to involve many biochemical and functional abnormalities, in both diabetic patients and animal models. oxidative stress is related to the progression of nerve dysfunction and that growth factors are involved in beneficial protection against functional nerve failure, the mechanism by which the oxidative stress controls diabetic neuropathy has not yet been elucidated. Insulin-like growth factor-1(IGF-1) is necessary both for Î²-cell function and as a protective agent against neurodegeneration in diabetes. Reactive Oxygen Species (ROS) are formed as natural toxic byproducts of the normal metabolism of oxygen. Cells typically defend themselves against ROS damage using enzymes such as superoxide dismutases, catalases, lactoperoxidases, and glutathione peroxidases
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Last date updated on September, 2014