Although transcriptional responsiveness varies over the lifetime, many brain genes still seem to be responsive to exercise in old animals and in animal models for neurodegenerative diseases. Using the senescence-accelerated SAMP8 mouse a non-transgenic model for studying aspects of progressive cognitive decline and Alzheimerââ¬â¢s disease (AD) we have recently shown that exercise training during adulthood (6 months of voluntary training on a running wheel, 3 alternate days per week) prevented or delayed processes associated with aging. Unveiling the exercise-responsive mechanisms of chromatin regulation and their pathophysiological implications may lead to the development of new preventive and/or therapeutic interventions for age-related disorders, including neurodegenerative conditions.
The top journals are peer reviewed scholarly journals. These provide high quality, meticulously reviewed and rapid publication, to cater the insistent need of scientific community. These journals are indexed with all their citations noted. The top open access journals are indexed in MEDLINE, PUBMED, SCOPUS, COPERNICUS, CAS, EBSCO and ISI.
Last date updated on September, 2024