alexa Neuron Open Access Journals|OMICS International|International Journal Of Neurorehabilitation

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Neuron Open Access Journals

It is recently accepted that vascular risk factors linked to cerebrovascular disease and stroke significantly increase the risk of developing AD. Since ischemic events in the elderly induce amyloid precursor protein, amyloid β and tau pathology, cerebral ischemia might be a key factor in the formation of the full picture of Alzheimer neurodegeneration over years. Most AD cases show silent ischemic episodes that can cause neuronal death, blood-brain barrier changes, inflammation response, neurofibrillary tangles and amyloid plaque formation. Alzheimer neuronal death occurs by defective cholesterol trafficking within the endocytic/lysosomal pathway caused by activated calpain-mediated cleavage of oxidative stress-injured Hsp70.1. Hsp70.1 dysfunction due to its cleavage leads to deprivation of ceramide at the lysosomal membrane via decrease of BMP, and eventually to destabilization of lysosomal membranes. The open access journals are peer reviewed scholarly journals of International Journal of Neurorehabilitation. The top open access journals are freely available on the public internet domain, allowing any end users to read, download, copy, distribute, prink, search or link to the full texts of the articles. These provide high quality, meticulously reviewed and rapid publication, to cater the insistent need of scientific community. These journals are indexed with all their citations noted. The top open access journals are indexed in SCOPUS, COPERNICUS, CAS, EBSCO and ISI.
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Last date updated on July, 2020