Anesthesia for neurosurgery requires balancing deep and effective anesthesia as well as postoperative analgesia versus the risks of delayed recovery and postoperative respiratory depression. This randomized, placebo-controlled, double-blind study was designed to evaluate the effect of magnesium sulfate on the total anesthetic and analgesic consumption using the clinical parameters in addition to the bispectral index (BIS) and neuromuscular monitoring using train-of-four (TOF). Magnesium is necessary for the presynaptic release of acetylcholine from nerve endings and may produce effects similar to calciumentry- blocking drugs.
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Last date updated on September, 2014