Ischemic stroke is one of the leading causes of death and disability in the world, but there are currently few effective clinical therapies for it. Alternatively, cell-based therapy has provided a promising hope to enhance tissue repair and functional recovery after stroke. Bone marrow stromal cells (BMSCs) can be easily obtained from patients themselves without ethical or immunological problems and can proliferate massively in vitro. After transplantation, its can promote the neurogenesis and angiogenesis in ischemic brain. HIF-1a is a transcription factor specifically activated by hypoxia, in proper low oxygen pressures, the level of HIF-1 a is regulated to maximal involving multiple mechanisms of control at the levels of mRNA expression, protein stability, nuclear translocation and transactivation activity, and play a protective role in the antiapoptosis after ischemia.
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Last date updated on September, 2014