Ischemic stroke is one of the leading causes of death and disability in the world, but there are currently few effective clinical therapies for it. Alternatively, cell-based therapy has provided a promising hope to enhance tissue repair and functional recovery after stroke. Bone marrow stromal cells (BMSCs) can be easily obtained from patients themselves without ethical or immunological problems and can proliferate massively in vitro. After transplantation, its can promote the neurogenesis and angiogenesis in ischemic brain. HIF-1a is a transcription factor specifically activated by hypoxia, in proper low oxygen pressures, the level of HIF-1 a is regulated to maximal involving multiple mechanisms of control at the levels of mRNA expression, protein stability, nuclear translocation and transactivation activity, and play a protective role in the antiapoptosis after ischemia.
Scholarly peer review is the process of subjecting an author'sscholarlywork, research, or ideas to the scrutiny of others who are experts in the same field, before a paper describing this work is published in a journal. The work may be accepted, considered acceptable with revisions, or rejected. Peer review requires a community of experts in a given (narrowly defined) field, who are qualified and able to perform reasonably impartial review.
Last date updated on July, 2020