Iron Chelation Therapy

Iron is absolutely essential to living cells and plays many important roles in energy production, oxygen transport and DNA synthesis. Although iron is crucial for cells, an excess of iron is toxic. In thalassemia patients, multiple blood transfusions and abnormal iron absorption cause iron overload and accumulation in tissues and organs. Consequently, reactive oxygen species (ROS) are produced from the iron-catalyzed Fenton reaction, causing oxidative tissue damage and organ dysfunctions. Iron chelation therapy is required, not just to restore iron balance, but also to reduce toxic iron species. Iron chelators, such as desferrioxamine (DFO), deferiprone (DFP) and deferasirox (DFX), are available for clinical use. Due to many side effects and drawbacks of available chelators, novel oral bidentate iron chelator CM1 is synthesized, it is an analogue and is more lipophilic than DFP. CM1 was able to bind both ferric and ferrous ions, and was also able to chelate plasma non-transferrin bound iron (NTBI), efficiently. CM1 was not toxic to peripheral blood mononuclear cells and liver cells in an in vitro study. Somdet Srichairatanakool https://www.omicsonline.org/open-access/toxicity-study-of-a-novel-oral-iron-chelator-nacetylaminohexyl-hydroxymethylpyridinone-cm-in-transgenic-bthalassemia-mice-vms.1000116.php?aid=16304 Vitamins & Minerals is the best peer-reviewed journals in related to nutrition scope journals from OMICS International publishing group. Articles published in this peer-reviewed journal have a rapid peer review process and are reviewed by at least two reviewers form the related expertise fields. Two comments like major and minor is followed for quality of the articles and final decision rests on the editor for the respective articles from editorial board of the journal. Vitamins & Minerals peer review journals covers the broader scopes stressing on the topics of hypervitaminosis, hypovitaminosis D, multivitamins, fat soluble vitamins, water soluble vitamins including but not limited to the above discussed fields. OMICS Group is one of the best international publishers with 700+ peer-reviewed journals along with eminent scientists in its Editorial Board and expert reviewers to carry rigorous peer-review process. The peer review process is highly appreciated by researchers globally. In addition to peer review open-access publishing, OMICS also provides E-books, Scholar Central and more than 3000+ International Scientific Conferences under its umbrella.

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Last date updated on September, 2024