Leptospirosis is one of the worldsâ most widespread zoonotic diseases, causing extensive vacuites of micro vessels in multiple organs. Faine reported that Leptospiral lesion disrupt the integrity of the cell membrane of endothelial cells lining small blood vessels in all parts of the body, and leading to capillary leakage and hemorrhage. Damage of blood vessels in the renal cortex leads to renal failure, and in the liver, cause haemorrhagic jaundices. In Tamilnadu state of India, several outbreaks of Leptospirosis had been reported. Jeyakumar et al. had reported the seroprevalence of Leptospirosis among the people involved in agricultural, livestock and veterinary activities in the city. Leptospires are corkscrew shaped bacteria (Spirochaetes), with many species divergence. The pathogenic Leptospira interrogans has several serovars, and reported to cause leptospirosis in many places in South India. Debnath et al. had reported a high incidence of Leptospirosis in rural people, particularly in people associated with agricultural activities. Hence, an investigation into herbal remedy for Leptospirosis could help villagers to take immediate remedial measures for this infection.
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Last date updated on September, 2020