|Epidemiological studies and clinical trials indicate conclusively that high serum cholesterol is a major risk factor for coronary heart disease and that lowering cholesterol levels reduces the risk .The three major sizes of lipoprotein particles in which cholesterol circulates in the plasma are: very low density lipoprotein cholesterol (VLDL-C) low density lipoprotein cholesterol (LDL-C) and high density lipoprotein cholesterol (HDL-C). Several large epidemiological studies suggest that for each 1 mg.dLâ1 increase in HDL-C, there is an accompanying 2% decrease in coronary heart disease risk in men and a 3% decrease in women. A low LDL-C level does not eliminate the risk impacted by a low HDL-C but a high HDL-C appears to offset some of the risk of a high LDL-C. HDL-C is the âgarbage trucksâ of the blood system, collecting cholesterol and dumping it into the liver. HDL-C plays a critical role in reverse cholesterol transport. It may retard atherogenesis by maintaining endothelial function
High-impact journals are those considered to be highly influential in their respective fields. The impact factor of journal provides quantitative assessment tool for grading, evaluating, sorting and comparing journals of similar kind. It reflects the average number of citations to recent articles published in science and social science journals in a particular year or period, and is frequently used as a proxy for the relative importance of a journal within its field. It is first devised by Eugene Garfield, the founder of the Institute for Scientific Information. The impact factor of a journal is evaluated by dividing the number of current year citations to the source items published in that journal during the previous two years.