The mRNA does not have any structure, as the recent concept of translation is stated as being analogous to a tape recording: mRNA freely passes through ribosomes, where it is read and translated into protein, on the codon to amino acid basis, with the help of tRNA-s as adaptors. Some mRNA structure is not necessary for this process, and some laboratories regard possible mRNA structures only as an unnecessary complication that slows down translation and reduces protein yield. However, thermodynamic studies oppose this view and determine that mRNA does have 3D structure. uring this study it was demonstrated that the FE (folding energy, dG) associated with coding sequences is significant and negative (-407 kcal/1000 bases, mean value), indicating that these sequences can form structures.
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Citation: Biro JC (2014) Suggestion to Upgrade the Canonical Concept of Translation. J Proteomics Bioinform 7: 112-120."
Last date updated on February, 2021