In principle, these nanocarriers can also avoid the uptake by the macrophagocytic system (MPS) by attenuating the receptor-mediated pathway. Moreover, the high surface to volume ratio of nanoparticles also leads to improved pharmacokinetics and biodistribution of the therapeutic proteins. A crucial feature of this delivery approach is the flexibility of tailoring the chemical and physical properties of the nanovehicle through controlled synthesis, assembly and chemical modifications. In summary, nanocarriers show several advantages for the effective and safe intracellular delivery of therapeutic proteins.
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Last date updated on July, 2014