Female Sprague-Dawley (SD) rats develop mammary adenocarcinoma in response to a single intragastric dose of 7, 12-dimethylbenz (a) Anthracene (DMBA), a polycyclic aromatic hydrocarbon (PHA). The mechanisms by which DMBA induces mammary tumours in rats have been well characterized. The carcinogen interacts with rapidly proliferating cells in the terminal end buds, forming DNA adducts, which in turn play a role in transforming normal terminal end bud cells into malignant cells. The susceptibility of SD rats to DMBA peaks at 55-60 days of age and is eliminated by ovariectomy, suggesting that the inducible action of the carcinogen depends on ovarian hormones.
Decrease in Aryl Hydrocarbon Receptor and 17Î²-Estradiol Receptor (A&B) Gene Expression in The Hypothalamus and The Pineal Gland, After Administration of Dimethylbenz (A) Anthracene, A Mammary Carcinogen, To Sprague-Dawley Female Rats.- Bernard Kerdelhue
Last date updated on June, 2014