|Magnetic resonance spectroscopy (MRS) can provide useful realtime in vivo PK properties when used to detect drugs containing nuclei with paramagnetic properties, e.g. 5-FU containing 19F. Similarly, Positron Emission Tomography (PET) can provide PK data when used to detect drugs with radionuclide labels, e.g. temozolamide containing 11C. These are excellent examples of non-invasive real time pharmacokinetic monitoring. Several factors that can be used as PD endpoints, such as tissue bioenergetic status, tissue metabolism and phospholipid membrane turnover can be monitored with the use of MRS. Changes in the spectra of several metabolites (ie, adenosine triphosphate, choline, phosphanolamine, lactate, N-acetylaspartate), following anti-cancer treatment, can be potentially used to monitor response to treatment.
Journal of Physical Medicine & Rehabilitation Open Access is one of the top online publishing journals for research from the field of Magnetic Resonance Spectroscopy. The open access articles published in this scholarly journal are reviewed by at least two reviewers of the associated fields. The journal publishes original research articles, reviews, case reports, short communications, etc and emphasizes theoretical and experimental work. To ensure high quality articles, both editors and reviewers actively participate in the peer review process and help in completing the review process within 21 days. As an important educational platform the journal provides scientists and researchers access to the newest trends and research outlooks. Please browse through the list of peer-reviewed journals to find the scientific publication of your interest.